TRPA1 anticorps (4th Cytoplasmic Loop)

N° du produit ABIN351103

Détail du produit anti-TRPA1 anticorps

Antigène: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Épitope: 4th Cytoplasmic Loop

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for TRPA1.

Immunogène: A synthetic from the 4th cytoplasmic loop of human transient receptor potential cation channel subfamily A member 1 (TRPA1, ANKTM1) conjugated to an immunogenic carrier protein was used as the immunogen.

Isotype: IgG

Information d'application

Indications d'application: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur TRPA1

Antigène: TRPA1 (Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1))

Autre désignation: TRPA1 (TRPA1 Produits)

Synonymes: anticorps trpa1, anticorps ANKTM1, anticorps Anktm1, anticorps CG5751, anticorps CG5761, anticorps CT18073, anticorps DmTRPA1, anticorps Dmel\\CG5751, anticorps TRPA, anticorps TRPA1, anticorps TrpA, anticorps dANKTM1, anticorps dTRPA, anticorps dTRPA1, anticorps dTrpA, anticorps dTrpA1, anticorps dtrpA1, anticorps trpA1, anticorps GLEAN_02449, anticorps FEPS, anticorps transient receptor potential cation channel, subfamily A, member 1a, anticorps Transient receptor potential cation channel A1, anticorps transient receptor potential cation channel subfamily A member 1, anticorps transient receptor potential A1, anticorps tryptophan synthase subunit alpha 1, anticorps transient receptor potential cation channel, subfamily A, member 1, anticorps TRPA cation channel homolog, anticorps trpa1a, anticorps TrpA1, anticorps TRPA1, anticorps LOC658860, anticorps LOC694623, anticorps trpA1, anticorps trpa1, anticorps Trpa1, anticorps trpa-1

Sujet: The structure of the protein encoded by this gene is highly related to both the protein ankyrin andtransmembrane proteins. The specific function of this protein has not yet been determined, however, studies indicate the function may involve a role in signal transduction and growth control.
Function: Receptor-activated non-selective cation channel involved in detection of sensations such as cold, pain or sounds perception. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Also involved in pain sensation triggered by capsaicin, the pungent ingredient in chilli peppers. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
Subcellular location: Membrane, Multi-pass membrane protein (Probable).
Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
Miscellaneous: Inhibited by ruthenium red, a potent blocker of TRPV channels. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1.