Insulin anticorps

N° du produit ABIN356107

Cet anticorps Souris Monoclonal détecte spécifiquement Insulin dans IHC (fro) et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Insulin anticorps (ABIN356107)

Antigène: Insulin (INS)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: D4B8

Détail du produit anti-Insulin anticorps

Specificité: AM02306PU-N recognizes Insulin, a major metabolic hormone produced by B cells of the pancreas.Aff. Const.:1.5 x 108 Mole/L

Attributs du produit: Synonyms: INS

Purification: Affinity Chromatography on Protein A

Immunogène: Purified human insulin. D4B8 has been derived from hybridization of X63-Ag8-653 myeloma cells with spleen cellsof Balb/c immunized with purified human insulin.

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry on Frozen Sections. ABIN356107 is suitable for use as the Detection antibody in a Sandwich ELISA withBM505 as the Capture antibody.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur Insulin

Antigène: Insulin (INS)

Autre désignation: Insulin

Sujet: Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.Synonyms: INS

ID gène: 3630

UniProt: P01308

Pathways: Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation