PRDM2 anticorps (N-Term)

N° du produit ABIN356378

Détail du produit anti-PRDM2 anticorps

Antigène: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Épitope: AA 1-347, N-Term

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRDM2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

Attributs du produit: Synonyms: PR domain zinc finger protein 2, KMT8, RIZ1, RIZ2, MTB-ZF, HUMHOXY1, Retinoblastomaprotein-interacting zinc finger protein, MTE-binding protein, GATA-3-binding protein G3B,Lysine N-methyltransferase 8

Purification: Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1.

Clone: 33AT1045

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100-1/500. ChIP (validated by third-party citation).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur PRDM2

Antigène: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Autre désignation: PRDM2 (PRDM2 Produits)

Synonymes: anticorps MGC114763, anticorps prdm2, anticorps riz, anticorps kmt8, anticorps riz1, anticorps riz2, anticorps mtb-zf, anticorps humhoxy1, anticorps PRDM2, anticorps HUMHOXY1, anticorps KMT8, anticorps MTB-ZF, anticorps RIZ, anticorps RIZ1, anticorps RIZ2, anticorps 4833427P12Rik, anticorps E330024L24Rik, anticorps Gm1033, anticorps Gm19732, anticorps Riz, anticorps Riz1, anticorps Znfpr1c1, anticorps PR domain containing 2, with ZNF domain S homeolog, anticorps PR domain containing 2, with ZNF domain b, anticorps PR domain containing 2, with ZNF domain, anticorps PR domain zinc finger protein 2, anticorps PR/SET domain 2, anticorps prdm2.S, anticorps prdm2b, anticorps prdm2, anticorps LOC100350859, anticorps PRDM2, anticorps Prdm2

Sujet: Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.Synonyms: GATA-3-binding protein G3B, HUMHOXY1, KMT8, Lysine N-methyltransferase 8, MTB-ZF, MTE-binding protein, PR domain zinc finger protein 2, RIZ1, RIZ2, Retinoblastoma protein-interacting zinc finger protein

ID gène: 7799

UniProt: Q13029