ATM anticorps (pSer1981)

N° du produit ABIN358435

Cet anticorps Lapin Polyclonal détecte spécifiquement ATM dans EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour ATM anticorps (pSer1981) (ABIN358435)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Enzyme Immunoassay (EIA)

Détail du produit anti-ATM anticorps

Épitope: pSer1981

Specificité: This antibody detects ABL pSer1981.

Purification: Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1

Poids moléculaire: 350644 Da

ID gène: 472, 9606

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus