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ATM anticorps (pSer1981)

ATM Reactivité: Humain EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN358435
  • Antigène Voir toutes ATM Anticorps
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Épitope
    • 32
    • 16
    • 15
    • 13
    • 9
    • 9
    • 8
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer1981
    Reactivité
    • 162
    • 84
    • 34
    • 4
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 138
    • 24
    • 6
    • 2
    Lapin
    Clonalité
    • 132
    • 38
    Polyclonal
    Conjugué
    • 81
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Cet anticorp ATM est non-conjugé
    Application
    • 74
    • 50
    • 39
    • 37
    • 28
    • 26
    • 22
    • 22
    • 19
    • 13
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects ABL pSer1981.
    Purification
    Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ATM Anticorps primaire
  • Indications d'application
    ELISA: 1/1,000. Dot Blot: 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Autre désignation
    ATM (ATM Produits)
    Synonymes
    anticorps ATM, anticorps Atm, anticorps CG6535, anticorps Dmel\\CG6535, anticorps Tefu, anticorps atm, anticorps atm/tefu, anticorps dATM, anticorps tef, anticorps Xatm, anticorps at1, anticorps atdc, anticorps tel1, anticorps telo1, anticorps AT1, anticorps ATA, anticorps ATC, anticorps ATD, anticorps ATDC, anticorps ATE, anticorps TEL1, anticorps TELO1, anticorps AI256621, anticorps C030026E19Rik, anticorps telomere fusion, anticorps ATM serine/threonine kinase L homeolog, anticorps ATM serine/threonine kinase, anticorps ataxia telangiectasia mutated, anticorps ataxia telangiectasia mutated (atm), anticorps serine/threonine-protein kinase ATM, anticorps tefu, anticorps atm.L, anticorps atm, anticorps ATM, anticorps EDI_100660, anticorps CpipJ_CPIJ001772, anticorps BDBG_08252, anticorps PAAG_02532, anticorps MCYG_05088, anticorps VDBG_06833, anticorps ACLA_015700, anticorps LOC5565620, anticorps MGYG_07634, anticorps PGTG_14279, anticorps Atm
    Sujet
    ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1
    Poids moléculaire
    350644 Da
    ID gène
    472, 9606
    UniProt
    Q13315
    Pathways
    Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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