GTPase NRas anticorps (C-Term)

N° du produit ABIN360039

Détail du produit anti-GTPase NRas anticorps

Antigène: GTPase NRas (NRAS)

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GTPase NRas est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to NRAS.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human NRAS.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur GTPase NRas

Antigène: GTPase NRas (NRAS)

Autre désignation: NRAS (NRAS Produits)

Synonymes: anticorps NRAS, anticorps AV095280, anticorps N-ras, anticorps ALPS4, anticorps NRAS1, anticorps NS6, anticorps N-RAS, anticorps fj99a10, anticorps wu:fj99a10, anticorps zgc:100761, anticorps zras-b1, anticorps H-RAS, anticorps HRAS, anticorps GTPase NRas, anticorps neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog, anticorps NRAS proto-oncogene, GTPase, anticorps neuroblastoma ras oncogene, anticorps neuroblastoma RAS viral oncogene homolog, anticorps Tsp_01117, anticorps nras.L, anticorps Nras, anticorps NRAS, anticorps nras

Sujet: NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).Synonyms: ALPS4, GTPase NRas, HRAS1, N-Ras, Transforming protein N-Ras, neuroblastoma RAS viral (v-ras) oncogene homolog

ID gène: 4893, 9606

UniProt: P01111

Pathways: Signalisation p53, Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling