PIP5K1A anticorps (N-Term)

N° du produit ABIN360478

Détail du produit anti-PIP5K1A anticorps

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIP5K1A est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to PIP5K1A.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIP5K1A.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PIP5K1A

Antigène: PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))

Autre désignation: PIP5K1A (PIP5K1A Produits)

Synonymes: anticorps Pip5k1b, anticorps pip5k1c, anticorps PIP5K1A, anticorps pip5k1b, anticorps Pipk5a, anticorps Pipk5b, anticorps pip5k1a, anticorps zgc:110576, anticorps im:7140933, anticorps zgc:158838, anticorps phosphatidylinositol-4-phosphate 5-kinase type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a, anticorps phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b, anticorps PIP5K1A, anticorps Pip5k1a, anticorps pip5k1a.L, anticorps pip5k1a, anticorps pip5k1aa, anticorps pip5k1ab

Sujet: Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.Synonyms: 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha, PIP5K1-alpha, PIP5KIalpha, Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha, PtdIns(4)P-5-kinase 1 alpha

ID gène: 8394, 9606

UniProt: Q99755

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA