Kv2.2 anticorps

N° du produit ABIN361380

Détail du produit anti-Kv2.2 anticorps

Antigène: Kv2.2 (KCNB2) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kv2.2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for the ~125k voltage gated potassium channel, Kv 2.2 subunit.

Réactivité croisée: Rat (Rattus)

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic peptide corresponding to amino acid residues specific to the Kv2.2 subunit conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-Kv2.2 (ABIN361380)

Gravagna, Knoeckel, Taylor, Hultgren, Ribera: "Localization of Kv2.2 protein in Xenopus laevis embryos and tadpoles." dans: The Journal of comparative neurology, Vol. 510, Issue 5, pp. 508-24, (2008) (PubMed).

Détails sur Kv2.2

Antigène: Kv2.2 (KCNB2) (Potassium Voltage-Gated Channel, Shab-Related Subfamily, Member 2 (KCNB2))

Autre désignation: KCNB2 (KCNB2 Produits)

Synonymes: anticorps KCNB2, anticorps si:ch211-193n21.1, anticorps Kv2.2, anticorps 9630047L19Rik, anticorps BB130875, anticorps XShab12, anticorps kcnb2, anticorps KV2.2, anticorps potassium voltage-gated channel subfamily B member 2, anticorps potassium voltage-gated channel, Shab-related subfamily, member 2, anticorps potassium channel, voltage gated Shab related subfamily B, member 2, anticorps potassium voltage gated channel, Shab-related subfamily, member 2, anticorps potassium channel, voltage gated Shab related subfamily B, member 2 S homeolog, anticorps KCNB2, anticorps kcnb2, anticorps LOC100051372, anticorps Kcnb2, anticorps kcnb2.S

Sujet: Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993, Yan et al., 2004, Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998, Burger and Ribera, 1996). Anti-Voltage Gated Potassium Channel, Kv2.2-Subunit Western blot of rat brain homogenate showing specific immunolabeling of the ~125k voltage-gated potassium channel, Kv2.2 (Control). The immunolabeling is blocked by preadsorption with the peptide used as antigen (Peptide Block).

Poids moléculaire: '100 kDa

ID gène: 621349

UniProt: Q63099