ATR anticorps (AA 426-430)
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- Antigène Voir toutes ATR Anticorps
- ATR (ATR serine/threonine kinase (ATR))
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Épitope
- AA 426-430
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ATR est non-conjugé
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Application
- Immunohistochemistry (IHC)
- Specificité
- The antibody detects endogenous level of total ATR protein.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
- Immunogène
- Peptide sequence around AA 426-430 (G-I-S-P-K) derived from Human ATR. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Isotype
- IgG
- Top Product
- Discover our top product ATR Anticorps primaire
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- Indications d'application
- Immunohistochemistry: 1:50-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- ATR (ATR serine/threonine kinase (ATR))
- Autre désignation
- ATR (ATR Produits)
- Synonymes
- anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps ATR serine/threonine kinase, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR, anticorps Atr
- Sujet
- ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
- Poids moléculaire
- 250 kDa
- NCBI Accession
- NP_001175
- UniProt
- Q13535
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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