IL2 Receptor beta anticorps

N° du produit ABIN371157

Détail du produit anti-IL2 Receptor beta anticorps

Antigène: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IL2 Receptor beta est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificité: This antibody recognises beta chain (Mr. 90-100 kDa) of the IL-2 Receptor. It does not block IL-2 binding. (Ref.1)

Attributs du produit: Synonyms: Interleukin-2 receptor subunit beta, IL-2 receptor subunit beta, IL2 Receptor beta, P70-75

Purification: Purified

Immunogène: Rat myeloma YB2/0 transfected with truncated mouse IL-2RB cDNA. (Ref. 1)

Clone: 5H4

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur IL2 Receptor beta

Antigène: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Autre désignation: CD122 / IL2RB (IL2RB Produits)

Synonymes: anticorps IL2RB, anticorps il-2rb, anticorps CD122, anticorps IL15RB, anticorps P70-75, anticorps IL2RBC, anticorps IL-15Rbeta, anticorps IL15Rbeta, anticorps Il-2/15Rbeta, anticorps Il-2Rbeta, anticorps p70, anticorps interleukin 2 receptor subunit beta, anticorps interleukin-2 receptor subunit beta, anticorps interleukin 2 receptor, beta, anticorps interleukin 2 receptor, beta chain, anticorps IL2RB, anticorps LOC510185, anticorps il2rb, anticorps Il2rb

Sujet: The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity, (ii) the beta chain that binds IL-2 with high affinity, and (ii) the common gamma chain (gc) that does not bind IL-2. (Ref.2) The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10e-11 M. (Ref.2) In mouse spleen, CD122 is expresed on ~30 % of CD8+ cells and all NK cells, but < 1 % of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells. (Ref.4) Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes. (Ref.1,4)Synonyms: IL-2 receptor subunit beta, IL2 Receptor beta, Interleukin-2 receptor subunit beta, P70-75

ID gène: 16185

UniProt: P16297

Pathways: Signalistation JAK/STAT, Growth Factor Binding