Band 3/AE1 anticorps (N-Term)

N° du produit ABIN372308

Détail du produit anti-Band 3/AE1 anticorps

Antigène: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Band 3/AE1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes CD233/SLC4A1 (N-term).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide corresponding to N-terminal residues of Human B3AT (Band 3 Anion Transport protein).

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 1 μg/mL. ELISA: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, 0.01 % Sodium Azide, 50 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur Band 3/AE1

Antigène: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Autre désignation: CD233 / SLC4A1 (SLC4A1 Produits)

Synonymes: anticorps AE1, anticorps BND3, anticorps CD233, anticorps DI, anticorps EMPB3, anticorps EPB3, anticorps FR, anticorps RTA1A, anticorps SW, anticorps WD, anticorps WD1, anticorps WR, anticorps Ae1, anticorps Empb3, anticorps l11Jus51, anticorps ae1, anticorps band3, anticorps MGC152771, anticorps zgc:111889, anticorps zgc:152771, anticorps si:dz180g5.1, anticorps LOC100136769, anticorps slc4a1, anticorps wd1, anticorps bnd3, anticorps epb3, anticorps cd233, anticorps empb3, anticorps rta1a, anticorps MGC80391, anticorps SLC4A1, anticorps BB3, anticorps EAT, anticorps solute carrier family 4 member 1 (Diego blood group), anticorps solute carrier family 4 (anion exchanger), member 1, anticorps solute carrier family 4 (anion exchanger), member 1a (Diego blood group), anticorps Band 3, anticorps erythrocyte membrane protein band 4.1 like 3, anticorps solute carrier family 4 member 1 (Diego blood group) L homeolog, anticorps solute carrier family 4 member 1, anticorps SLC4A1, anticorps Slc4a1, anticorps slc4a1a, anticorps LOC100136769, anticorps EPB41L3, anticorps slc4a1.L, anticorps slc4a1

Sujet: SLC4A1 (also known as Band 3 protein, Anion exchanger 1) is the most abundant integral protein of human erythrocyte membranes and functions as the major anion transporter polypeptide of erythrocytes, exchanging bicarbonate ions for chloride ions. It plays a central role in structure and function of red blood cells and in acid-secreting cells in the kidney. Band 3 is a 90-100 kD protein, its microheterogeneity is ascribed mainly to the structural heterogeneity of the carbohydrate moiety. The C-terminal portion of the molecule spans the membrane several times, and is responsible for anion transport. The N-terminal portion, comprising almost half of the polypeptide chain of Band 3, is located inside the red cell and interacts with cytoskeletal and cytoplasmic proteins such as ankyrin. There are several Band 3 mutations known in man, which cause several diseases including hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the Band 3 protein and is common in areas where Plasmodium falciparum malaria is endemic.Synonyms: AE1, Anion Exchanger 1, Anion exchange protein 1, Band 3 anion transport protein, EPB3, Solute carrier family 4 member 1

Poids moléculaire: 102 kDa

ID gène: 6521

NCBI Accession: NP_000333

UniProt: P02730