CDT1 anticorps (C-Term)

N° du produit ABIN374262

Cet anticorps anti-CDT1 Polyclonal Chèvre (ABIN374262) détecte spécifiquement CDT1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CDT1 anticorps (C-Term) (ABIN374262)

Antigène: CDT1 (Chromatin Licensing and DNA Replication Factor 1 (CDT1))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp CDT1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CDT1 anticorps

Épitope: C-Term

Séquence: C-ARLAHQTRAE EGL

Specificité: This antibody detects CDT1 at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogène: Peptide from C Terminus of the protein sequence according to NP_112190.2. Genename: CDT1

Information d'application

Indications d'application: Peptide ELISA: Limit dilution 1: 64000. Western Blot: 1-3 μg/mL. Approx 65 kDa band observed in Human Brain lysates (predictedMW of 65 kDa according to NP_112190.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Détails sur CDT1

Antigène: CDT1 (Chromatin Licensing and DNA Replication Factor 1 (CDT1))

Autre désignation: CDT1

Sujet: Cdt1 and its inhibitor Geminin are important regulators of replication licensing. A critical balance between both proteins functions to ensure that each origin only fires once during the cell cycle. Cdt1 cooperates with Cdc6 to promote the loading of the MCM complex onto chromatin to form the pre-replication complex. Overexpression of Cdt1 leads to aberrant replication and activation of DNA damage checkpoints. It is also associated with a predisposition for malignant transformation.Synonyms: DNA replication factor Cdt1, DUB, Double parked homolog, RIS2

ID gène: 81620

NCBI Accession: NP_112190

UniProt: Q9H211

Pathways: Signalisation MAPK, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA