AOC3 anticorps (C-Term, Internal Region)
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- Antigène Voir toutes AOC3 Anticorps
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
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Épitope
- C-Term, Internal Region
- Reactivité
- Humain, Souris, Rat
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AOC3 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Séquence
- C-DEDPSFYSAD SIY
- Specificité
- This antibody detects internal AOC3 / VAP1.
- Réactivité croisée (Details)
- Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human
- Purification
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
- Immunogène
- Peptide from the internal region (near the C Terminus) of the protein sequence according to NP_003725.1 Genename: AOC3
- Top Product
- Discover our top product AOC3 Anticorps primaire
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- Indications d'application
- Peptide ELISA: antibody detection limit dilution 1: 64000. Western blot: Preliminary experiments gave an approx 55 kDa band in Human Adipose andLung lysates after 0.01 μg/mL antibody staining. Please note that currently we cannot findan explanation in the literature for the band we observe given the calculated size of84.5 kDa according to NP_003725.1. The 55 kDa band was successfully blocked byincubation with the immunizing peptide. We would appreciate any feedback from peoplein the field - have any results been reported with other antibodies/lysates? Have anyfurther splice variants/modified forms been reported?Immunohistochemistry on paraffin sections: 3-5 μg/mL. In Human Liver shows membranousstaining in sinusoid lining cells surrounding hepatocytes.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
- Autre désignation
- AOC3 / VAP1 (AOC3 Produits)
- Synonymes
- anticorps HPAO, anticorps SSAO, anticorps VAP-1, anticorps VAP1, anticorps aoc2, anticorps BOLAO, anticorps amine oxidase, copper containing 3, anticorps amine oxidase, copper containing 3 L homeolog, anticorps AOC3, anticorps aoc3.L, anticorps Aoc3
- Sujet
- VAP1, upregulated in response to inflammation, is a cell adhesion protein that participates in lymphocyte recirculation, by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells, in an L selectin independent fashion. VAP1 also displays a monoamine oxidase activity, catalyzing the deamination of methylamine to produce formaldehyde. Upregulation of VAP1 has been reported in Alzheimer's disease, where increased levels of formaldehyde are responsible for b amyloid cross linkage and plaque formation, significantly contributing to the pathogenesis of this disease.Synonyms: Copper amine oxidase, HPAO, Membrane primary amine oxidase, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1
- ID gène
- 8639, 9606
- UniProt
- Q16853
- Pathways
- Feeding Behaviour
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