ARNTL anticorps (both Isoforms, Internal Region)

N° du produit ABIN375102

Détail du produit anti-ARNTL anticorps

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Épitope: both Isoforms, Internal Region

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ARNTL est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody is expected to recognize both reported isoforms (NP_001025444.1, NP_001025443.1) of BMAL1

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Bovine, Canine, Pig.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence REKITTNCYKFKIKD, from the internal region of the protein sequence according to NP_001169.3, NP_001025444.1.

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ARNTL

Antigène: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Autre désignation: ARNTL / BMAL1 (ARNTL Produits)

Synonymes: anticorps BMAL1, anticorps BMAL1c, anticorps JAP3, anticorps MOP3, anticorps PASD3, anticorps TIC, anticorps bHLHe5, anticorps Bmal1, anticorps ARNTL, anticorps xBmal1, anticorps arntl, anticorps Arnt3, anticorps BMAL1b, anticorps bmal1b', anticorps aryl hydrocarbon receptor nuclear translocator like, anticorps aryl hydrocarbon receptor nuclear translocator-like, anticorps aryl hydrocarbon receptor nuclear translocator like S homeolog, anticorps ARNTL, anticorps Arntl, anticorps arntl.S, anticorps arntl

Sujet: BMAL1 is a putative transcription factor involved in the generation of biological rhythms. It activates cycling transcription of Period (PER) and Timeless (TIM) by binding to the E-box (3'-CACGTG-5') present in their promoters. BMAL1 gene cyc mutants don't display PER and TIM cycling, and are completely arrhythmic. Efficient DNA binding requires dimerization with another bHLH protein, BMAL1 forms a heterodimer with Clock in order to activate PER and TIM transcription.Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 1, BHLHE5, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5, MOP3, Member of PAS protein 3, PAS domain-containing protein 3, PASD3, bHLH-PAS protein JAP3, bHLHe5

ID gène: 406, 9606

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, L'effet Warburg