ERCC1 anticorps (N-Term)

N° du produit ABIN375196

Détail du produit anti-ERCC1 anticorps

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Épitope: N-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to ERCC1.

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography

Immunogène: Peptide with sequence DPGKDKEGVPQPS-C, from the N Terminus of the protein sequence

Information d'application

Indications d'application: ELISA: 1/64000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1 (ERCC1 Produits)

Synonymes: anticorps COFS4, anticorps RAD10, anticorps UV20, anticorps Ercc-1, anticorps ercc1, anticorps T12H1.18, anticorps T12H1_18, anticorps UV REPAIR DEFICIENT 7, anticorps UVR7, anticorps ERCC excision repair 1, endonuclease non-catalytic subunit, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 1, anticorps DNA excision repair protein ERCC-1, anticorps nucleotide repair protein, anticorps excision repair cross-complementation group 1 L homeolog, anticorps excision repair cross-complementation group 1, anticorps ERCC1, anticorps Ercc1, anticorps CC1G_04546, anticorps CpipJ_CPIJ013903, anticorps PITG_13719, anticorps ercc1, anticorps ercc1.L

Sujet: The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1 XPF complex makes the 5'incision. Elevated levels of ERCC1 have also been reported in Cisplatin resistant cells.Synonyms: COFS4, DNA excision repair protein ERCC-1, UV20

ID gène: 2067

NCBI Accession: NP_001974

UniProt: P07992

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response