ITCH anticorps (Internal Region)

N° du produit ABIN375211

Détail du produit anti-ITCH anticorps

Antigène: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp ITCH est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to ITCH.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide with sequence C-EIKSHDLKPNGGN, from the internal region of the protein sequence

Information d'application

Indications d'application: ELISA: 1/32000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ITCH

Antigène: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Autre désignation: ITCH / AIF4 (ITCH Produits)

Synonymes: anticorps AIF4, anticorps AIP4, anticorps NAPP1, anticorps dJ468O1.1, anticorps 6720481N21Rik, anticorps 8030492O04Rik, anticorps A130065M08, anticorps C230047C07Rik, anticorps itchy E3 ubiquitin protein ligase, anticorps itchy, E3 ubiquitin protein ligase, anticorps ITCH, anticorps Itch

Sujet: ITCH interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells (referenced from Swiss-Prot).Synonyms: Atrophin-1-interacting protein 4, E3 ubiquitin-protein ligase Itchy homolog, NAPP1, NFE2-associated polypeptide 1

ID gène: 83737

NCBI Accession: NP_113671

UniProt: Q96J02

Pathways: Activation of Innate immune Response, CXCR4-mediated Signaling Events