BID anticorps
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- Antigène Voir toutes BID Anticorps
- BID (BH3 Interacting Domain Death Agonist (BID))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp BID est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- Human Bid
- Attributs du produit
- Mouse Anti-Human Bid-UNLB
- Purification
- Purified
- Immunogène
- Recombinant Bid
- Clone
- SB50a
- Isotype
- IgG2b
- Top Product
- Discover our top product BID Anticorps primaire
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- Indications d'application
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- Applications: ELISA - Quality tested WB - Quality tested IP
- Working Dilutions: ELISA Purified (UNLB) antibody ≤ 2 g/mL Immunoblotting Purified (UNLB) antibody ≤ 3 g/mL
- Volume d'échantillon
- 0,2 mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- 0.1 mg of purified immunoglobulin in 0.2 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C
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- Antigène
- BID (BH3 Interacting Domain Death Agonist (BID))
- Autre désignation
- Bid (BID Produits)
- Synonymes
- anticorps FP497, anticorps 2700049M22Rik, anticorps AI875481, anticorps AU022477, anticorps BID, anticorps bid, anticorps si:ch211-238n5.6, anticorps fp497, anticorps xbid, anticorps DKFZp469E066, anticorps BH3 interacting domain death agonist, anticorps BH3 interacting domain death agonist S homeolog, anticorps BID, anticorps Bid, anticorps bida, anticorps bid.S, anticorps bid
- Sujet
- Members of the Bcl-2 family are pro- or antiapoptotic proteins that process one or several of the Bcl-2 homology (BH) domains. Bid is a proapoptotic, BH3-domain-only member or BH3-only protein (BOP) of the Bcl-2 family. Bid is localized in the cytosolic fraction of living cells as an inactive precursor. Activation of Bid occurs upon its cleavage by caspase-8 in the Fas and TNF- α apoptotic signaling pathways. Recent studies have suggested that Bid is also cleaved and activated by granzyme B, calpain and lysosomal extracts. Cleaved Bid translocates to mitochondria where it induces the release of cytochrome c from the intermembrane space of the mitochondria. The release of cytochrome c initiates apoptosis by activating downstream caspases through binding to Apaf-1. Bid has also been shown to interact with with Bax, another Bcl-2 family protein, to trigger a conformational change in Bax leading to the dimerization and integration of Bax into the outer mitochondrial membrane and activating the release of cytochrome c.
- Pathways
- Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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