TOLLIP anticorps

N° du produit ABIN377023

Détail du produit anti-TOLLIP anticorps

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOLLIP est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Specificité: Human Tollip, Does not react to TLR2, TLR4, TLR6, TLR7, TLR8 and TLR10 recombinant proteins Tollip, Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLR- mediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins. 1-6

Attributs du produit: Mouse Anti-Human Tollip-UNLB

Purification: Purified

Immunogène: Recombinant Tollip

Clone: SB40a

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: Flow Cytometry Immunoblotting Enzyme-Linked-Immunosorbent-Assay (ELISA)
• Working Dilutions: Since applications vary, you should determine the optimum working dilution of the product that is appropriate for your specific need.

Volume d'échantillon: 0,2 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur TOLLIP

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Autre désignation: Tollip (TOLLIP Produits)

Synonymes: anticorps IL-1RAcPIP, anticorps 4930403G24Rik, anticorps 4931428G15Rik, anticorps fk22a02, anticorps im:7145391, anticorps wu:fk22a02, anticorps zgc:76985, anticorps TOLLIP, anticorps GB17961, anticorps tollip, anticorps tollip1, anticorps tollipa, anticorps TOLIP, anticorps toll interacting protein, anticorps toll-interacting protein, anticorps toll-interacting protein-like, anticorps toll interacting protein L homeolog, anticorps toll interacting protein S homeolog, anticorps Toll-interleukine I receptor interacting protein I, anticorps TOLLIP, anticorps Tollip, anticorps tollip, anticorps LOC552034, anticorps LOC100169858, anticorps tollip.L, anticorps tollip.S, anticorps LOC100136122

Sujet: Toll-interacting protein, is a 30 kDa adaptor protein that is a component of the signaling pathway of IL-1 and Toll-like receptors. Tollip forms a complex with IRAK (IL-1 receptor associated kinase) and inhibits IL-1-induced signaling by blocking IRAK phosphorylation. The co-recruitment of MyD88 triggers IRAK autophosphorylation, which in turn leads to the rapid dissociation of IRAK and Tollip. Tollip is also an important signaling component of the TLR2 and TLR4 pathways by playing an inhibitory role in TLR-mediated cell activation. Tollip also associates with Tom1 (target of Myb1) forming a complex which regulates endosomal trafficking of ubiquitinated proteins.