Src anticorps

N° du produit ABIN387822

Cité dans 3 publications. Cet anticorps anti-Src Monoclonal Souris (Clone 17AT28) (ABIN387822) détecte spécifiquement Src dans WB et IF. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Src anticorps (ABIN387822)

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Src est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 17AT28

Détail du produit anti-Src anticorps

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This Src antibody is generated from mouse immunized with a recombinant protein of full length human SRC.

Isotype: IgG1

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:500. WB: 1:2000. WB: 1:100~500. WB: 1:100~500. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Src (ABIN387822)

Nicholson, Seta, Lee, Morgan: "MicroRNA-203 mimics age-related aortic smooth muscle dysfunction of cytoskeletal pathways." dans: Journal of cellular and molecular medicine, Vol. 21, Issue 1, pp. 81-95, (2017) (PubMed).

Marcotte, Smith, Sanguin-Gendreau, McDonough, Muller: "Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 8, pp. 2808-13, (2012) (PubMed).

Chen, Li, Zhang, Yi, Chen, Wang, Zhang: "Src-stimulated IRTKS phosphorylation enhances cell migration." dans: FEBS letters, Vol. 585, Issue 19, pp. 2972-8, (2011) (PubMed).

Détails sur Src

Antigène: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Autre désignation: Src

Sujet: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Poids moléculaire: 59835

ID gène: 6714

NCBI Accession: NP_005408, NP_938033

UniProt: P12931

Pathways: Signalistation JAK/STAT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling