MCL-1 anticorps (AA 191-226)

N° du produit ABIN388105

Cet anticorps Lapin Polyclonal détecte spécifiquement MCL-1 dans WB, FACS et IHC (p). Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 4+ publications.

Aperçu rapide pour MCL-1 anticorps (AA 191-226) (ABIN388105)

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCL-1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB00961

Détail du produit anti-MCL-1 anticorps

Épitope: AA 191-226

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-226 amino acids from human MCL1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:2000. IHC-P: 1:10~50. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-MCL-1 (ABIN388105)

Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." dans: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Tsang, Tang, Chan, Co, Au Yeung, Yau, Kong, Fung, Kwok: "P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells." dans: Apoptosis : an international journal on programmed cell death, Vol. 16, Issue 5, pp. 524-35, (2011) (PubMed).

Johnson, Lucas, Muthusamy, Smith, Edwards, De Lay, Croce, Grever, Byrd: "Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia." dans: Blood, Vol. 108, Issue 4, pp. 1334-8, (2006) (PubMed).

Yamane, Dylla, Muijtjens, Weissman: "Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 9, pp. 3312-7, (2005) (PubMed).

Détails sur MCL-1

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Autre désignation: MCL1

Sujet: The Mcl-1 protein belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Poids moléculaire: 37337

ID gène: 4170

NCBI Accession: NP_001184249, NP_068779, NP_877495

UniProt: Q07820

Pathways: Signalisation MAPK