BIK anticorps (BCL2-Interacting Killer (Apoptosis-Inducing)) (AA 39-74)

Details for Product anti-BIK Antibody No. ABIN388114, Fournisseur: Connectez-vous pour afficher
Antigène
  • BIK
  • Biklk
  • Blk
  • Nbk
  • BIP1
  • BP4
  • NBK
  • si:dkey-31f5.6
  • BCL2 interacting killer
  • BCL2-interacting killer
  • BCL2-interacting killer (apoptosis-inducing)
  • BIK
  • Bik
  • bik
Épitope
AA 39-74, BH3 Domain
35
21
8
8
7
6
4
3
3
3
2
2
1
1
1
Reactivité
Humain, Souris
122
34
11
4
Hôte
Lapin
115
8
Clonalité (Clone)
Polyclonal ()
Conjugué
Cet anticorp BIK est non-conjugé
5
5
4
4
4
4
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
117
81
64
31
21
11
10
5
4
2
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène This Bik BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-74 AA from human Bik BH3 Domain.
Clone RB3381
Isotype Ig Fraction
Specificité This Bik BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50~80 amino acids selected from the N-terminal region (BH3 domain) of human Bik.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Plasmids, Primers & others Plasmids, Primers & others BIK products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Bik (BIK Antibody Extrait)
Sujet The Bik protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
Synonyms: Bcl-2 interacting killer, Apoptosis inducer NBK, BP4, BIP1
Poids moléculaire 18016 DA
ID gène 638
UniProt Q13323
Pathways Positive Regulation of Endopeptidase Activity
Indications d'application WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) (AA 39-74), (BH3 Domain) antibody (ABIN388114) The anti-Bik BH3 domain Pab (ABIN388114) is used in Western blot to detect Bik BH3 in...
Immunohistochemistry (IHC) image for anti-BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) (AA 39-74), (BH3 Domain) antibody (ABIN388114) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) (AA 39-74), (BH3 Domain) antibody (ABIN388114) Bik Antibody (BH3) (ABIN388114) western blot analysis in A549 cell line lysates (35 µ...
Western Blotting (WB) image for anti-BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) (AA 39-74), (BH3 Domain) antibody (ABIN388114) All lanes : Anti-hBik-BH3 at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: R...
Produit citée dans: Sass, Shembade, Haimerl, Lamoureux, Hashemolhosseini, Tannapfel, Tiegs: "TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 10, pp. 7042-9, 2007 (PubMed). Méthode utilisée: Western Blotting (WB)

Background publications Gillissen, Essmann, Graupner, Stärck, Radetzki, Dörken, Schulze-Osthoff, Daniel: "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway." dans: The EMBO journal, Vol. 22, Issue 14, pp. 3580-90, 2003 (PubMed).

Germain, Mathai, Shore: "BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria." dans: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 18053-60, 2002 (PubMed).

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