ATM anticorps (pSer1981)

N° du produit ABIN389888

L’anticorps Lapin Polyclonal anti-ATM a été validé pour IF et DB. Il convient pour détecter ATM dans des échantillons de Humain. Il y a 1 publication disponible.

Aperçu rapide pour ATM anticorps (pSer1981) (ABIN389888)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Immunofluorescence (IF), Dot Blot (DB)

Clone: RB8121

Détail du produit anti-ATM anticorps

Épitope: pSer1981

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Phospho-ATM-pS1981 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-ATM (ABIN389888)

Matsuda, Sanpei, Wakai, Kubota, Osawa, Hirose, Sakata, Kobayashi, Fujimaki, Takamura, Yamagiwa, Yano, Ohkoshi, Aoyagi: "Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase." dans: International journal of clinical and experimental pathology, Vol. 7, Issue 5, pp. 2032-43, (2015) (PubMed).

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.

Poids moléculaire: 350687

ID gène: 472

NCBI Accession: NP_000042

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus