Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Homologie
M, Pig, Rb
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This CAMK2D (CAMK2 delta) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 448-478 amino acids from the C-terminal region of human CAMK2D (CAMK2 delta).
anticorps CAMKD, anticorps CAMK1, anticorps Camk2, anticorps Camki, anticorps RATCAMKI, anticorps camk2, anticorps camkd, anticorps camkII, anticorps 2810011D23Rik, anticorps 8030469K03Rik, anticorps [d]-CaMKII, anticorps mKIAA4163, anticorps calcium/calmodulin dependent protein kinase II delta, anticorps calcium/calmodulin-dependent protein kinase II delta, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II delta S homeolog, anticorps calcium/calmodulin dependent protein kinase (CaM kinase) II delta, anticorps calcium/calmodulin-dependent protein kinase II, delta, anticorps CAMK2D, anticorps Camk2d, anticorps camk2d.S, anticorps camk2d
Sujet
CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Expression of CAMK2 delta is significantly increased in patients suffering from dilated cardiomyopathy.