MCL-1 anticorps

N° du produit ABIN400763

L’anticorps anti-MCL-1 Monoclonal Souris est utilisé pour la détection de MCL-1 dans des échantillons de Humain. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour MCL-1 anticorps (ABIN400763)

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MCL-1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 8C6D4B1

Détail du produit anti-MCL-1 anticorps

Specificité: This antibody recognizes Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1).

Réactivité croisée (Details): Species reactivity (tested):Human.

Attributs du produit: Synonyms: BCL2L3, Bcl-2-like protein 3, mcl1/EAT, EAT, r004, Induced myeloid leukemia celldifferentiation protein Mcl-1, Bcl-2-related protein

Purification: Protein G Chromatography.

Immunogène: Ni-NTA purified recombinant protein MCL1 expressed in E. Coli strain M15.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000. Western blot: 1/200-1/1000. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MCL-1

Antigène: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Autre désignation: MCL1

Sujet: MCL1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004

ID gène: 4170

UniProt: Q07820

Pathways: Signalisation MAPK