Tamalin/GRASP anticorps (N-Term)

N° du produit ABIN401381

Détail du produit anti-Tamalin/GRASP anticorps

Antigène: Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))

Épitope: N-Term

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tamalin/GRASP est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Specificité: This antibody is directed against Tamalin protein.

Réactivité croisée (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Mouse.

Purification: Affinity chromatography

Immunogène: Synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/4,000 - 1/20,000. Western Blot: 1/500 - 1/3,000. Immunoprecipitation: 1 μg.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.03 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur Tamalin/GRASP

Antigène: Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))

Autre désignation: GRASP (GRASP Produits)

Synonymes: anticorps GRASP, anticorps tamalin, anticorps TAMALIN, anticorps general receptor for phosphoinositides 1 associated scaffold protein, anticorps GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein, anticorps GRASP, anticorps grasp, anticorps Grasp

Sujet: Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domaincontaining protein that interacts with group 1 metabotropic glutamate receptors (mGluRs). The PDZ domaincontaining amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs. The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins. It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.Synonyms: GRP1-associated scaffold protein, General receptor for phosphoinositides 1-associated scaffold protein

ID gène: 56149

NCBI Accession: NP_062391

UniProt: Q9JJA9