TRKB anticorps (pTyr515)
-
- Antigène Voir toutes TRKB (NTRK2) Anticorps
- TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
-
Épitope
- pTyr515
-
Reactivité
- Humain, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp TRKB est non-conjugé
-
Application
- Immunofluorescence (IF)
- Specificité
- Antibody AP09481PU detects endogenous levels of TrkB only when phosphorylated at Tyrosine 515.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse and Rat
- Purification
- Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Immunogène
- The antiserum was produced against synthesized phosphopeptide derived from Human TrkB around the phosphorylation site of Tyrosine 515 (P-Q-Y-pF-G).
- Top Product
- Discover our top product NTRK2 Anticorps primaire
-
-
- Indications d'application
-
Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at-20 °C.
-
- Antigène
- TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))
- Autre désignation
- TrkB (NTRK2 Produits)
- Synonymes
- anticorps trkb, anticorps trkb-b, anticorps xtrkb, anticorps si:ch211-220b11.1, anticorps trkB2, anticorps NTRK2, anticorps ntrk2, anticorps gp145-trkb, anticorps TRKB, anticorps GP145-TrkB, anticorps trk-B, anticorps AI848316, anticorps C030027L06Rik, anticorps Tkrb, anticorps trkB, anticorps RATTRKB1, anticorps TRKB1, anticorps Trk-B, anticorps TrkB, anticorps neurotrophic receptor tyrosine kinase 2, anticorps neurotrophic receptor tyrosine kinase 2 L homeolog, anticorps neurotrophic tyrosine kinase, receptor, type 2b, anticorps neurotrophic receptor tyrosine kinase 2 S homeolog, anticorps neurotrophic tyrosine kinase, receptor, type 2, anticorps NTRK2, anticorps ntrk2.L, anticorps ntrk2b, anticorps ntrk2.S, anticorps ntrk2, anticorps Ntrk2
- Sujet
- Neurotrophins activate tyrosine kinase receptors of the Trk family (TrkA, TrkB and TrkC) and they all share a common low affinity receptor (p75NTR or p75). Although p75NTR does not appear to directly transduce NGF signals, this receptor appears to increase the responsiveness of the trk receptors and plays a role in the retrograde transport of neurotrophin signals from axon terminals to the cell body. The expression of trk gene neurotrophin receptors in mouse is tabulated by Barbacid (1994). NGF binds with high affinity and activates the TrkA tyrosine kinase receptor, which is apparently responsible for signal transduction. BDNF activates the TrkB tyrosine kinase receptor, which it shares with NT-4. NT-3 activates the TrkC tyrosine kinase receptor, but can also activate TrkA and TrkB receptors in certain cell systems. NT-4 primarily activates the TrkB tyrosine kinase receptor, which it shares with BDNF.Synonyms: BDNF/NT-3 growth factors receptor, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TRKB, TrkB tyrosine kinase
- Poids moléculaire
- 140 kDa
- ID gène
- 4915
- NCBI Accession
- NP_001007098
- UniProt
- Q16620
- Pathways
- Signalisation RTK, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport
-