p53 anticorps (Tumor Protein P53) (AA 20-31)

Details for Product anti-TP53 Antibody No. ABIN4219254
Antigène
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Épitope
AA 20-31
134
80
79
72
66
66
66
59
58
54
51
45
41
41
37
30
28
24
22
21
21
18
17
16
15
15
15
15
15
15
14
14
13
13
12
11
11
10
10
9
9
9
8
8
8
8
8
7
7
7
7
7
7
6
6
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
2344
501
466
249
100
64
63
32
26
22
22
17
16
7
6
6
5
4
4
4
3
3
3
2
2
1
1
1
Hôte
Souris
1648
769
7
5
1
1
1
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp p53 est non-conjugé
89
62
48
41
40
40
40
39
39
38
33
32
14
12
12
12
12
11
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
2
2
2
Application
ELISA, Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
1835
765
747
574
436
413
369
155
109
102
99
89
75
41
32
16
15
15
13
3
2
2
1
1
1
1
1
1
1
1
1
Options
Immunogène Recombinant human p53 (transcription domain within the NH2 terminus)
Clone Bp53-11
Isotype IgG2a
Specificité P53
 Réactivité croisée Humain
Purification Protein A affinity column
Plasmids, Primers & others Plasmids, Primers & others p53 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation P53 (TP53 Antibody Extrait)
Sujet Excellent marker for wild-type and mutant forms of human p53 antigen. The antibody stains positively approx. 60 % of investigated carcinoma of lung, breast, colon, stomach, esophagus, pancreas, urinary bladder and testis, head and neck tumors, T-cell Leuk
ID gène 7157
UniProt P04637
Pathways Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Indications d'application IHC: 1:500, when using the APAAP method
Restrictions For Research Use only
Format Lyophilized
Reconstitution reconstitue with 1 mL deionized water
Concentration 0.025 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium azide, 0.5 % BSA
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C/-20 °C
Stockage commentaire 2-8°C, extended storage at -20°C, avoid repeated freeze-thaw cycles
Images (Fournisseur)
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 20-31) antibody (ABIN4219254) p53 staining in human squamous cell carcinoma (image courtesy of J.Heß, University Ho...
Produit citée dans: Zarka, Han, Edelson, Rosenblum: "Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin." dans: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 13, Issue 2, pp. 240-3, 2003 (PubMed).

Ohtaké, Cheng, Ida, Suzuki, Ohshiro, Zhang, Saku: "Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry." dans: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 31, Issue 10, pp. 590-7, 2002 (PubMed).

Homann, Nees, Conradt, Dietz, Weidauer, Maier, Bosch: "Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 2, pp. 290-6, 2001 (PubMed).

Andl, Kahn, Pfuhl, Nicola, Erber, Conradt, Klein, Helbig, Dietz, Weidauer, Bosch: "Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control." dans: Cancer research, Vol. 58, Issue 1, pp. 5-13, 1998 (PubMed).

Petersen, Song, Hügle-Dörr, Oldenburg, Bautz: "Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries." dans: Molecular & general genetics : MGG, Vol. 249, Issue 4, pp. 425-31, 1996 (PubMed).

Stephen, Helminen, Lane: "Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions." dans: Journal of molecular biology, Vol. 248, Issue 1, pp. 58-78, 1995 (PubMed).

Fisher, Gillett, Vojtĕsek, Barnes, Millis: "Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation." dans: British journal of cancer, Vol. 69, Issue 1, pp. 26-31, 1994 (PubMed).

Bártek, Bártková, Lukás, Stasková, Vojt?sek, Lane: "Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies." dans: The Journal of pathology, Vol. 169, Issue 1, pp. 27-34, 1993 (PubMed).

Bártek, Bártková, Vojtĕsek, Stasková, Rejthar, Kovarík, Lane: "Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro." dans: International journal of cancer, Vol. 46, Issue 5, pp. 839-44, 1990 (PubMed).

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