HCN1 anticorps (C-Term)
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- Antigène Voir toutes HCN1 Anticorps
- HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))
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Épitope
- AA 778-910, C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp HCN1 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody detects HCN1 cyclic nucleotidegated Channel at ~100 kDa. No cross reactivity against HCN2.
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human. - Attributs du produit
- Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, Braincyclic nucleotide-gated channel 1
- Purification
- Protein G Chromatography
- Immunogène
- Fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 (also known aspotassium/sodium hyperpolarization-activated) cyclic nucleotide-gated channel
- Clone
- S70-28
- Isotype
- IgG1
- Top Product
- Discover our top product HCN1 Anticorps primaire
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- Indications d'application
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Western blot: 1 - 10 μg/mL (if results are off, try using the lysate without boiling. Immunoprecipitation. Immunohistochemistry: 0.1 - 1.0 μg/mL (Perox).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS pH 7.4 containing 50 % Glycerol and 0.09 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
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Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch. - Date de péremption
- 12 months
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- Antigène
- HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))
- Autre désignation
- HCN1 / BCNG1 (HCN1 Produits)
- Synonymes
- anticorps BCNG-1, anticorps BCNG1, anticorps HAC-2, anticorps Bcng1, anticorps C630013B14Rik, anticorps HAC2, anticorps hyperpolarization activated cyclic nucleotide gated potassium channel 1, anticorps hyperpolarization-activated cyclic nucleotide-gated potassium channel 1, anticorps hyperpolarization-activated, cyclic nucleotide-gated K+ 1, anticorps hcn1, anticorps HCN1, anticorps Hcn1
- Sujet
- Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (3).Synonyms: Brain cyclic nucleotide-gated channel 1, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
- ID gène
- 84390
- UniProt
- Q9JKB0
- Pathways
- Asymmetric Protein Localization
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