KCNQ1 anticorps (AA 2-101)

N° du produit ABIN452408

Détail du produit anti-KCNQ1 anticorps

Antigène: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Épitope: AA 2-101

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KCNQ1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody detects KCNQ1 K+ Channel at ~75 kDa.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat

Attributs du produit: Synonyms: KCNA8, KCNA9, KVLQT1, KQT-like 1, Potassium voltage-gated channel subfamily KQTmember 1, Voltage-gated potassium channel subunit Kv7.1, IKs producing slowvoltage-gated potassium channel subunit alpha KvLQT1

Purification: Protein G chromatography

Immunogène: Fusion protein amino acid 2-101 of human KCNQ1 (Kv7. 1, KvLQT1

Clone: S37A-10

Isotype: IgG1

Information d'application

Indications d'application: Western blot: 1 - 10 μg/mL (if results are off, try using thelysate without boiling). Immunoprecipitation. Immunohistochemistry on frozen sections: 0.1 - 1.0 μg/mL (Perox).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol and 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur KCNQ1

Antigène: KCNQ1 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1))

Autre désignation: KCNQ1 (KCNQ1 Produits)

Synonymes: anticorps ATFB1, anticorps ATFB3, anticorps JLNS1, anticorps KCNA8, anticorps KCNA9, anticorps KVLQT1, anticorps Kv1.9, anticorps Kv7.1, anticorps LQT, anticorps LQT1, anticorps RWS, anticorps SQT2, anticorps WRS, anticorps CG12215, anticorps CG12915, anticorps CG33135, anticorps DKCNQ, anticorps Dmel\\CG33135, anticorps dKCNQ, anticorps kcnq1, anticorps KCNQ1, anticorps kqt-3, anticorps kv7.1, anticorps Kvlqt1, anticorps KvLQT-1, anticorps kcnq1-A, anticorps xkvlqt1, anticorps zgc:158384, anticorps AW559127, anticorps Kcna9, anticorps KvLQT1, anticorps potassium voltage-gated channel subfamily Q member 1, anticorps KCNQ potassium channel, anticorps potassium voltage-gated channel, KQT-like subfamily, member 1, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 1, anticorps voltage gated potassium channel subunit, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 1 L homeolog, anticorps potassium voltage-gated channel, subfamily Q, member 1, anticorps KCNQ1, anticorps KCNQ, anticorps kcnq1, anticorps Kcnq1, anticorps kcnq1.L

Sujet: Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gate channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (3) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (4, 5).Synonyms: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KCNA8, KCNA9, KQT-like 1, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, Voltage-gated potassium channel subunit Kv7.1

ID gène: 3784

UniProt: P51787

Pathways: Negative Regulation of Hormone Secretion, Sensory Perception of Sound