ELOVL4 anticorps

N° du produit ABIN4620376

Détail du produit anti-ELOVL4 anticorps

Antigène: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELOVL4 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects ELOV4, expressed in the retina and at much lower level in the brain.

Purification: Affinity chromatography

Immunogène: Synthetic peptdide derived from the human ELOV4 protein

Isotype: IgG

Information d'application

Indications d'application: Western Blot (1: 400 starting dilution).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Détails sur ELOVL4

Antigène: ELOVL4 (ELOVL Fatty Acid Elongase 4 (ELOVL4))

Autre désignation: ELOVL4 (ELOVL4 Produits)

Synonymes: anticorps elovl4, anticorps MGC122553, anticorps ADMD, anticorps CT118, anticorps ISQMR, anticorps STGD2, anticorps STGD3, anticorps elongation of very long chain fatty acids protein 4, anticorps ELOVL fatty acid elongase 4, anticorps elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4, anticorps CpipJ_CPIJ002114, anticorps CpipJ_CPIJ003687, anticorps CpipJ_CPIJ011025, anticorps CpipJ_CPIJ013819, anticorps ELOVL4, anticorps elovl4, anticorps Elovl4

Sujet: Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-terminal amino acids and truncation of the protein. Elovl4 is expressed in the retina and only a limited number of mammalian other tissues, including skin, with unknown function. In a mouse model with the 5-bp deletion in the Elovl4 gene, mice in the heterozygous state (Elovl4(+/del)) demonstrate progressive photoreceptor degeneration. Homozygous mice (Elovl4(del/del)) display scaly, wrinkled skin, have severely compromised epidermal permeability barrier function, and die within a few hours after birth. Lipid analyses of epidermis from Elovl4(del/del) mice show a decrease in very long-chain fatty acids (VLFAs) in both the ceramide/glucosylceramide and the free fatty-acid fractions. ELOVL4 is required for generating VLFA critical for epidermal barrier function.Synonyms: 3-keto acyl-CoA synthase ELOVL4, Elongation of very long chain fatty acids protein 4

ID gène: 6785

NCBI Accession: NP_073563

UniProt: Q9GZR5