CTDSP1 anticorps (C-Term, N-Term)

N° du produit ABIN360805

Détail du produit anti-CTDSP1 anticorps

Antigène: CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))

Épitope: AA 1-250, C-Term, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CTDSP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to CTDSP1-V250.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CTDSP1-V250 protein.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur CTDSP1

Antigène: CTDSP1 (CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 (CTDSP1))

Autre désignation: CTDSP1 (CTDSP1 Produits)

Synonymes: anticorps CTDSP1, anticorps NIF3, anticorps NLI-IF, anticorps NLIIF, anticorps SCP1, anticorps fj83f12, anticorps im:7141428, anticorps wu:fj83f12, anticorps zgc:113169, anticorps GIP, anticorps Nif3, anticorps CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1, anticorps CTD small phosphatase 1, anticorps carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, anticorps CTDSP1, anticorps Ctdsp1, anticorps ctdsp1, anticorps HCAG_04820, anticorps CTRG_06220

Sujet: CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF, 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.Synonyms: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, NIF3, NLI-IF, NLI-interacting factor 3, NLIIF, SCP1, Small C-terminal domain phosphatase 1

ID gène: 58190, 9606

UniProt: Q9GZU7