TPSAB1 anticorps (AA 65-275)

N° du produit ABIN4886754

Détail du produit anti-TPSAB1 anticorps

Antigène: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Épitope: AA 65-275

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPSAB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Tryptase alpha/beta-1(TPSAB1) detection. Tested with WB, IHC-P, ELISA in Human.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Tryptase alpha/beta-1(TPSAB1) detection. Tested with WB, IHC-P, ELISA in Human.
Gene Name: tryptase alpha/beta 1
Protein Name: Tryptase alpha/beta-1

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human Mast Cell Tryptase recombinant protein (Position: H65-P275). Human Mast Cell Tryptase shares 77% and 76.1% amino acid (aa) sequence identity with mouse and rat Mast Cell Tryptase, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur TPSAB1

Antigène: TPSAB1 (Tryptase alpha/beta 1 (TPSAB1))

Autre désignation: TPSAB1 (TPSAB1 Produits)

Synonymes: anticorps TPS1, anticorps TPS2, anticorps TPSB1, anticorps PMCT7, anticorps tpsab1, anticorps tryptaseB, anticorps tryptaseC, anticorps MMCP-7, anticorps Mcp-7, anticorps Mcp7, anticorps Mcpt7, anticorps rMCP-7, anticorps AV011504, anticorps MMCP-6, anticorps Mcp-6, anticorps Mcp6, anticorps Mcpt6, anticorps tryptase alpha/beta 1, anticorps tryptase, anticorps tryptase beta 2 (gene/pseudogene), anticorps tryptase beta 2, anticorps TPSAB1, anticorps MCT7, anticorps tpsab1, anticorps TPSB2, anticorps Tpsab1, anticorps Tpsb2

Sujet: Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. In addition, these genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

Synonyms: alpha II | Lung tryptase | MCP 7 | Pituitary tryptase | Skin tryptase | TPS 1 | TPS1 | TPS2 | TPSAB1 | TPSAB1 protein | TPSB1 | Tryptase 1 | Tryptase alpha 1 | tryptase alpha I included | Tryptase alpha II | tryptase alpha II included | tryptase alpha included | tryptase alpha/beta 1 | Tryptase beta 1 | tryptase beta I included | Tryptase I | tryptase I included | Tryptase III | Tryptase skin | Q15661

ID gène: 7177

UniProt: Q15661