Beclin 1 anticorps (AA 110-190)
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- Antigène Voir toutes Beclin 1 (BECN1) Anticorps
- Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
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Épitope
- AA 110-190
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Beclin 1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- Beclin-1 is a protein encoded by the ECN1 gene which is approximately 51,9 kDa. Beclin-1 is localised to the cytoplasm, Golgi apparatus and mitochondrion membrane. It is involved in the autophagy pathway, deubiquitination, metabolism of proteins, apelin signalling pathway and nanomaterial induced apoptosis. The beclin-1 protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which plays a role in multiple membrane trafficking pathways. PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. It also plays a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Beclin-1 is ubiquitously expressed. Mutations in the ECN1 gene can result in cervical cancer, breast cancer and Wolfram syndrome. STJ97761 was affinity-purified from rabbit. This antibody detects endogenous beclin-1.
- Specificité
- Beclin-1 Mouse Monoclonal Antibody (5C2) detects endogenous levels of BECN1
- Attributs du produit
- Mouse Monoclonal to Beclin-1.
- Purification
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Immunogène
- synthetic peptide derived from Beclin-1
- Clone
- 5C2
- Isotype
- IgG1
- Top Product
- Discover our top product BECN1 Anticorps primaire
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- Indications d'application
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WB 1:1000-2000
IHC 1:100-200 - Commentaires
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Ubiquitous.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze/thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Antigène
- Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))
- Autre désignation
- Beclin-1 (BECN1 Produits)
- Synonymes
- anticorps beclin-1, anticorps atg6, anticorps vps30, anticorps beclin1, anticorps Beclin-1, anticorps becn1, anticorps zgc:73097, anticorps ATG6, anticorps VPS30, anticorps 4921513J16Rik, anticorps 5430417M23Rik, anticorps Atg6, anticorps beclin 1, anticorps beclin 1, autophagy related, anticorps beclin 1 protein, anticorps beclin-1, anticorps beclin family protein, anticorps beclin 1, autophagy related L homeolog, anticorps BECN1, anticorps becn1, anticorps atg6, anticorps CpipJ_CPIJ011087, anticorps PTRG_07825, anticorps SJAG_01876, anticorps Becn1, anticorps becn1.L
- ID gène
- 8678
- UniProt
- Q14457
- Pathways
- Autophagy
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