ERK1 anticorps

N° du produit ABIN4901491

Cet anticorps Souris Monoclonal détecte spécifiquement ERK1 dans IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ERK1 anticorps (ABIN4901491)

Antigène: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERK1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5E9

Détail du produit anti-ERK1 anticorps

Fonction: ERK1 is a protein encoded by the MAPK1 gene which is approximately 41,3 kDa. ERK1 is localised to the cytoplasm, cytoskeleton ad nucleus. It is involved in RET signalling, activated TLR4 signalling, the IL-2 pathway, regulation of lipid metabolism and insulin signalling-generic cascades. This protein falls under the MAP kinase family and acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Upon its activation, it translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. ERK1 is expressed in the cells of the nervous system, blood, lung, liver and skin. Mutations in the MAPK1 gene may result in small intestine neuroendocrine neoplasm. STJ97780 was developed from clone 5E9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of MAPK3.

Specificité: ERK1 Mouse Monoclonal Antibody (5E9) detects endogenous levels of MAPK3

Attributs du produit: Mouse Monoclonal to ERK1.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Immunogène: Recombinant peptide derived from ERK1

Isotype: IgG1

Information d'application

Indications d'application: IHC 1:100-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur ERK1

Antigène: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Autre désignation: ERK1

ID gène: 5595

UniProt: P27361

Pathways: Signalisation MAPK, Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins