MARCKS anticorps

N° du produit ABIN4904308

Détail du produit anti-MARCKS anticorps

Antigène: MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARCKS est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: The expression of a major cellular substrate for protein kinase C, the MARCKS protein, is regulated in a cell-, tissue-, and developmental stage-specific fashion, in addition, this expression can be stimulated acutely by various cytokines in certain cell types (1). MARCKS) binds calmodulin and is a predominant, specific substrate of PKC which is phosphorylated during macrophage and neutrophil activation, growth factor-dependent mitogenesis and neurosecretion, it is redistributed from plasma membrane to cytoplasm when phosphorylated and is involved in leukocyte motility. It has been reported that MARCKS is a filamentous (F) actin crosslinking protein, with activity that is inhibited by PKC-mediated phosphorylation and by binding to calcium-calmodulin. MARCKS may be a regulated crossbridge between actin and the plasma membrane, and modulation of the actin crosslinking activity of the MARCKS protein by calmodulin and phosphorylation represents a potential convergence of the calcium-calmodulin and PKC signal transduction pathways in the regulation of the actin cytoskeleton (2).

Purification: Affinity purification

Immunogène: A synthetic peptide of human MARCKS.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur MARCKS

Antigène: MARCKS (Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS))

Autre désignation: MARCKS (MARCKS Produits)

Synonymes: anticorps 80K-L, anticorps MACS, anticorps PKCSL, anticorps PRKCSL, anticorps KINC, anticorps Macs, anticorps marcks, anticorps MGC89127, anticorps MARCKS, anticorps macs, anticorps wu:fb55c06, anticorps wu:fb92d04, anticorps wu:fc19b04, anticorps wu:fc44a10, anticorps zgc:110235, anticorps fc34g03, anticorps fc38c06, anticorps wu:fc34g03, anticorps wu:fc38c06, anticorps zgc:109978, anticorps myristoylated alanine rich protein kinase C substrate, anticorps myristoylated alanine-rich protein kinase C substrate, anticorps methyl binding domain106, anticorps myristoylated alanine-rich protein kinase C substrate b, anticorps myristoylated alanine-rich protein kinase C substrate S homeolog, anticorps myristoylated alanine-rich protein kinase C substrate a, anticorps MARCKS, anticorps Marcks, anticorps marcks, anticorps mbd106, anticorps marcksb, anticorps marcks.S, anticorps marcksa

ID gène: 4082

UniProt: P29966