Nischarin anticorps

N° du produit ABIN4904536

Détail du produit anti-Nischarin anticorps

Antigène: Nischarin (NISCH)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nischarin est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

Purification: Affinity purification

Immunogène: Recombinant protein of human NISCH.

Isotype: IgG

Information d'application

Indications d'application: WB 1:200-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur Nischarin

Antigène: Nischarin (NISCH)

Autre désignation: NISCH (NISCH Produits)

Synonymes: anticorps NISCH, anticorps IRAS, anticorps 1200007D05Rik, anticorps 3202002H23Rik, anticorps AW494485, anticorps I-1, anticorps IR1, anticorps hIRAS, anticorps nischarin, anticorps nischarin S homeolog, anticorps NISCH, anticorps Cyan7822_6841, anticorps nisch.S, anticorps nisch, anticorps Nisch

ID gène: 11188

UniProt: Q9Y2I1