ELAVL1 anticorps

N° du produit ABIN4909093

Détail du produit anti-ELAVL1 anticorps

Antigène: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ELAVL1 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogène: This ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein.

Clone: 4C3

Isotype: IgG1

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ELAVL1

Antigène: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Autre désignation: ELAVL1 (ELAVL1 Produits)

Synonymes: anticorps ELAV1, anticorps HUR, anticorps Hua, anticorps MelG, anticorps HuR, anticorps 2410055N02Rik, anticorps W91709, anticorps elra, anticorps fa25f08, anticorps fb59a02, anticorps fc60g02, anticorps hua, anticorps wu:fa25f08, anticorps wu:fb59a02, anticorps wu:fc60g02, anticorps zHuA, anticorps Elavl1, anticorps Xel-1, anticorps elav1, anticorps elrA, anticorps hur, anticorps melg, anticorps p36, anticorps ElrA, anticorps elavl1, anticorps elavl1-a, anticorps elavl1-b, anticorps ELAV like RNA binding protein 1, anticorps ELAV-like protein 1, anticorps ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R), anticorps ELAV like RNA binding protein 1a, anticorps ELAV like RNA binding protein 1 L homeolog, anticorps ELAV like RNA binding protein 1 S homeolog, anticorps ELAVL1, anticorps Elavl1, anticorps elav1, anticorps elavl1a, anticorps elavl1.L, anticorps elavl1.S

Sujet:

Synonyms: HUR, Hua, MelG, ELAV1, ELAV-like protein 1, Hu-antigen R, ELAVL1

Background: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

ID gène: 1994

UniProt: Q15717

Pathways: AMPK Signaling