TGFBR2 anticorps (pTyr259) (AbBy Fluor® 555)
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- Antigène Voir toutes TGFBR2 Anticorps
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
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Épitope
- pTyr259
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Reactivité
- Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TGFBR2 est conjugé à/à la AbBy Fluor® 555
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris, Rat
- Homologie
- Human
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthesised phosphopeptide derived from human TGF beta Receptor II around the phosphorylation site of Tyr259
- Isotype
- IgG
- Top Product
- Discover our top product TGFBR2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
- Autre désignation
- TGFBR2 (TGFBR2 Produits)
- Synonymes
- anticorps AAT3, anticorps FAA3, anticorps LDS1B, anticorps LDS2B, anticorps MFS2, anticorps RIIC, anticorps TAAD2, anticorps TGFR-2, anticorps TGFbeta-RII, anticorps 1110020H15Rik, anticorps AU042018, anticorps DNIIR, anticorps RIIDN, anticorps TBR-II, anticorps TbetaR-II, anticorps TbetaRII, anticorps TGFBR2, anticorps TBETA-RII, anticorps TGFBRII, anticorps TGF-beta 2, anticorps Tgfbr2T, anticorps cb537, anticorps tgfbr2, anticorps wu:fj05c10, anticorps zgc:110498, anticorps transforming growth factor beta receptor 2, anticorps transforming growth factor, beta receptor II, anticorps transforming growth factor, beta receptor 2, anticorps transforming growth factor beta receptor 2b, anticorps TGFBR2, anticorps Tgfbr2, anticorps tgfbr2b
- Sujet
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Synonyms: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGF-beta receptor type-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Background: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
- ID gène
- 7048
- UniProt
- P37173
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