KCNA3
Reactivité: Humain, Souris, Rat
FACS
Hôte: Lapin
Polyclonal
PE
Indications d'application
Optimal dilution of the KCNA3 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
After reconstitution, the KCNA3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
KCNA3
(Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3))
anticorps Kv1.3-glyb, anticorps kv1.3, anticorps Kv1.3B, anticorps kcna3b-a, anticorps HGK5, anticorps HLK3, anticorps HPCN3, anticorps HUKIII, anticorps KV1.3, anticorps MK3, anticorps PCN3, anticorps Kca1-3, anticorps Kv1.3, anticorps Mk-3, anticorps cKv1.1, anticorps potassium voltage-gated channel subfamily A member 3, anticorps potassium channel, voltage gated shaker related subfamily A, member 3 S homeolog, anticorps potassium voltage-gated channel, shaker-related subfamily, member 3, anticorps KCNA3, anticorps kcna3.S, anticorps Kcna3
Sujet
Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene. This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. And Kv1.3 has been reported to be expressed in the inner mitochondrial membrane in lymphocytes. The apoptotic protein Bax has been suggested to insert into theouter mitochondrial membrane and occlude the pore of Kv1.3 via a lysine residue. Thus, Kv1.3 modulation may be one of many mechanisms that contribute to apoptosis.