Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 25-205) anticorps

Détails pour le produit réf. ABIN4951533
Antigène
  • INrf2
  • KLHL19
  • INRF2
  • mKIAA0132
  • Inrf2
  • fb36f11
  • keap1
  • wu:fb36f11
  • KEAP1
  • klhl19
  • zgc:171654
  • kelch like ECH associated protein 1
  • kelch-like ECH-associated protein 1
  • Kelch-like ECH-associated protein 1
  • kelch-like ECH-associated protein 1a
  • kelch like ECH associated protein 1 L homeolog
  • kelch-like ECH-associated protein 1b
  • KEAP1
  • Keap1
  • keap1a
  • keap1
  • keap1.L
  • keap1b
Épitope
AA 25-205
29
15
11
8
8
5
4
3
2
2
2
2
1
1
1
1
1
1
Reactivité
Humain
149
78
68
11
10
9
7
5
5
5
4
3
3
2
1
Hôte
Lapin
127
25
2
Clonalité
Polyclonal
Conjugué
Inconjugué
7
6
6
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
121
71
66
25
18
15
13
7
6
6
4
2
1
1
Options
Immunogène Amino acids 25-205 of human KEAP1 were used as the immunogen for the KEAP1 antibody.
Isotype IgG
Purification Antigen affinity
Antigène
Autre désignation KEAP1 (KEAP1 Antibody Extrait)
Sujet KELCH-LIKE ECH-ASSOCIATED PROTEIN 1 is a protein that in humans is encoded by the KEAP1 gene. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.
UniProt Q14145
Pathways Maintenance of Protein Location
Indications d'application Optimal dilution of the KEAP1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL
Restrictions For Research Use only
Buffer 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock -20 °C
Stockage commentaire After reconstitution, the KEAP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Images (Fournisseur)
Image no. 1 for anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (AA 25-205) antibody (ABIN4951533) Western blot testing of human 1) HeLa, 2) MCF7 and 3) SW620 lysate wtih KEAP1 antibod...