PINX1 anticorps

N° du produit ABIN4952167

Détail du produit anti-PINX1 anticorps

Antigène: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINX1 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids DHIKVQVKNNHLGLGATINNEDNWIAHQDD of human PINX1 were used as the immunogen for the PINX1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PINX1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the PINX1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur PINX1

Antigène: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Autre désignation: PINX1 (PINX1 Produits)

Synonymes: anticorps PINX1, anticorps LPTL, anticorps LPTS, anticorps 2210403I16Rik, anticorps 2610028A01Rik, anticorps 67-11-3, anticorps AU024023, anticorps LPTS1, anticorps RGD1566025, anticorps PIN2/TERF1 interacting telomerase inhibitor 1, anticorps PIN2/TERF1 interacting, telomerase inhibitor 1, anticorps PINX1, anticorps Pinx1

Sujet: PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.

UniProt: Q96BK5