RASA1 anticorps

N° du produit ABIN4952372

Détail du produit anti-RASA1 anticorps

Antigène: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASA1 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids AQQHVLKKLLAITELLQQKQNQYTKTNDVR of human RASA1 were used as the immunogen for the RASGAP antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the RASGAP antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the RASGAP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur RASA1

Antigène: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Autre désignation: RASGAP / RASA1 (RASA1 Produits)

Synonymes: anticorps CG9209, anticorps D-RasGAP, anticorps Dmel\\CG9209, anticorps RAS-GAP, anticorps RasGAP, anticorps RasGap, anticorps rasGap, anticorps CM-AVM, anticorps CMAVM, anticorps GAP, anticorps PKWS, anticorps RASA, anticorps RASGAP, anticorps p120GAP, anticorps p120RASGAP, anticorps GAPX, anticorps Rasa, anticorps Gap, anticorps vacuolar peduncle, anticorps RAS p21 protein activator 1, anticorps vap, anticorps RASA1, anticorps Rasa1

Sujet: RASA1, also known as RAS p21 protein activator 1 or RASGAP, is a 120- kDa cytosolic human protein. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

UniProt: P20936

Pathways: Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals