Aurora A anticorps

N° du produit ABIN3030072

Détail du produit anti-Aurora A anticorps

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Aurora A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Purified

Immunogène: This AURKA antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human AURKA.

Clone: 1364CT291-108-155

Isotype: IgG1 kappa

Information d'application

Indications d'application: Titration of the AURKA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:25,Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the AURKA antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Aurora A

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Autre désignation: AURKA (AURKA Produits)

Synonymes: anticorps AIK, anticorps ARK1, anticorps AURA, anticorps AURORA2, anticorps BTAK, anticorps PPP1R47, anticorps STK15, anticorps STK6, anticorps STK7, anticorps AIRK1, anticorps AU019385, anticorps AW539821, anticorps Ark1, anticorps Aurora-A, anticorps Ayk1, anticorps IAK, anticorps IAK1, anticorps Stk6, anticorps 87A7-9/2, anticorps Aur-A, anticorps AurA, anticorps CG3068, anticorps Dmel\\CG3068, anticorps aur-A, anticorps aurA, anticorps ck10, anticorps ck[10], anticorps l(3)87Ac, anticorps l(3)ck10, anticorps ARK-1, anticorps Eg2, anticorps aik, anticorps ark1, anticorps aur-a, anticorps aura, anticorps aurka-a, anticorps aurora2, anticorps btak, anticorps stk15, anticorps stk6, anticorps stk7, anticorps pEg2, anticorps wu:fb37c10, anticorps wu:fc02c02, anticorps zgc:100912, anticorps AURKA, anticorps aurka, anticorps aurora kinase A, anticorps aurora A, anticorps aurora kinase A L homeolog, anticorps hypothetical protein, anticorps aurora kinase A S homeolog, anticorps AURKA, anticorps Aurka, anticorps aurA, anticorps aurka.L, anticorps aurka, anticorps Aurora-A, anticorps aurka.S

Sujet: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

UniProt: O14965

Pathways: Cycle Cellulaire, Asymmetric Protein Localization