PARP1 anticorps (pSer177)

N° du produit ABIN3032163

Cet anticorps anti-PARP1 est un anticorps Lapin Polyclonal détectant PARP1 dans ELISA et DB. Adapté pour Humain.

Aperçu rapide pour PARP1 anticorps (pSer177) (ABIN3032163)

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP1 est non-conjugé

Application: ELISA, Dot Blot (DB)

Détail du produit anti-PARP1 anticorps

Épitope: pSer177

Réactivité croisée (Details): Expected species reactivity: Hamster, Mouse, Rat

Purification: Antigen affinity purified

Immunogène: This phospho-PARP antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS177 of human PARP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the phospho-PARP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the phospho-PARP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur PARP1

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Autre désignation: PARP

Sujet: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

UniProt: P09874

Pathways: Apoptose, Caspase Cascade in Apoptosis, Réparation de l'ADN, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location