PARP1 anticorps (pThr368)

N° du produit ABIN3032273

L’anticorps anti-PARP1 Polyclonal Lapin est utilisé pour la détection de PARP1 dans des échantillons de Humain. Il a été validé pour ELISA et DB.

Aperçu rapide pour PARP1 anticorps (pThr368) (ABIN3032273)

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP1 est non-conjugé

Application: ELISA, Dot Blot (DB)

Détail du produit anti-PARP1 anticorps

Épitope: pThr368

Fonction: Phospho-PARP1 Antibody (pT368)

Purification: Antigen affinity purified

Immunogène: This Phospho-PARP1 (T368) Antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT368 of human PARP1.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Phospho-PARP1 (T368) Antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles

Stock: -20 °C

Stockage commentaire: Aliquot the Phospho-PARP1 (T368) Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PARP1

Antigène: PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))

Autre désignation: PARP

Sujet: Phospho-PARP1 (T368) Antibody specifically detects PARP1 phosphorylated at the threonine 368 site. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Phosphorylation-dependent PARP1 signaling studies may also benefit from our < a href=../tds/phospho-parp-antibody-ps177-f48726>phospho-PARP1 (Ser177) antibody page focused on DNA damage response and chromatin stress pathway regulation.

UniProt: P09874

Pathways: Apoptose, Caspase Cascade in Apoptosis, Réparation de l'ADN, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location