DIO3 anticorps

N° du produit ABIN498490

Détail du produit anti-DIO3 anticorps

Antigène: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIO3 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of DIO3 protein. (region surrounding Glu66)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DIO3

Antigène: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Autre désignation: DIO3 (DIO3 Produits)

Synonymes: anticorps 5DIII, anticorps DIOIII, anticorps txdi3, anticorps dioiii, anticorps XL-15, anticorps itdi3, anticorps D3, anticorps TXDI3, anticorps iodothyronine deiodinase 3, anticorps deiodinase, iodothyronine, type 3, anticorps deiodinase, iodothyronine, type III, anticorps deiodinase, iodothyronine type III, anticorps deiodinase, iodothyronine, type 3 L homeolog, anticorps DIO3, anticorps dio3, anticorps Dio3, anticorps dio3.L

Sujet: DIO3 (deiodinase, iodothyronine, type III), also known as D3, 5DIII, TXDI3 or DIOIII, is a single-pass type II membrane protein that belongs to the iodothyronine deiodinase family of proteins. Members of the iodothyronine deiodinase family play an important role in thyroid hormone metabolism. Expressed in placenta and various fetal tissues, DIO3 localizes to the cell membrane and plays an important role regulating the activity of thyroid hormones during morphogenesis. More specifically, DIO3 functions as the major physiologic inactivator of thyroid hormones, catalyzing the inner-ring deiodination (the removal of iodine groups) of 3,5,3',5'-tetraiodothyronine (T4) and 3,5,3'-triiodothyronine (T3) to their inactive metabolites 3,3',5'-triiodothyronine (RT3 or reverse T3) and 3,3'-diiodothyronine (T2), respectively. Through its ability to inactivate thyroid hormones, DIO3 effects thermoregulation, gene expression and energy metabolism, as well as a number of other important reactions in cell maintenance and differentiation.Synonyms: 5DIII, DIOIII, ITDI3, TXDI3, Type 3 DI, Type III iodothyronine deiodinase, Type-III 5'-deiodinase

Poids moléculaire: approx. 30 kDa

ID gène: 1735

NCBI Accession: NP_001353

UniProt: P55073

Pathways: Hormone Activity