CXCL12 anticorps

N° du produit ABIN498530

Détail du produit anti-CXCL12 anticorps

Antigène: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXCL12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of SDF-1 protein. Species Reactivity: Tested: Human, Mouse and Rat.

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH~7.2 0.05% Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.

Date de péremption: 12 months

Détails sur CXCL12

Antigène: CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

Autre désignation: CXCL12 / SDF1 (CXCL12 Produits)

Synonymes: anticorps IRH, anticorps PBSF, anticorps SCYB12, anticorps SDF1, anticorps TLSF, anticorps TPAR1, anticorps CINC-1, anticorps Gro1, anticorps Pbsf, anticorps Scyb12, anticorps Sdf1, anticorps Tlsf, anticorps Tpar1, anticorps Fsp, anticorps KC, anticorps Mgsa, anticorps N51, anticorps Scyb1, anticorps gro, anticorps sdf-1, anticorps sdf1, anticorps xSDF-1, anticorps SDF-1, anticorps cxcl12, anticorps sdf-1a, anticorps sdf1a, anticorps wu:fa55e10, anticorps wu:fc16h12, anticorps wu:fj84c02, anticorps C-X-C motif chemokine ligand 12, anticorps C-X-C motif chemokine ligand 1, anticorps chemokine (C-X-C motif) ligand 12, anticorps chemokine (C-X-C motif) ligand 1, anticorps C-X-C motif chemokine ligand 12 L homeolog, anticorps chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1), anticorps CXCL12, anticorps cxcl12, anticorps Cxcl1, anticorps Cxcl12, anticorps cxcl12.L, anticorps cxcl12a

Sujet: The C-X-C or alpha chemokine family is characterized by a pair of cysteine residues separated by a single amino acid and primarily functions as chemoattractants for neutrophils. The C-X- C family includes IL-8, NAP-2, MSGA and stromal cell-derived factor-1, or SDF-1. SDF-1 was originally described as a pre-B cell stimulatory factor, but has now been shown to function as a potent chemoattractant for T cells and monocytes, but not neutrophils. Receptors for the C-X-C family are G protein-coupled, seven-pass, transmembrane domain proteins which include IL-8RA, IL-8RB and fusin (also designated LESTR or CXCR-4). Fusin is highly homologous to the IL-8 receptors, sharing 37% sequence identity at the amino acid level. The IL-8 receptors bind to IL-8, NAP-2 and MSGA, while fusin binds to its cognate ligand, SDF-1. Fusin has been identified as the major co-receptor for T-tropic HIV-1, and SDF-1 has been shown to inhibit HIV-1 infection. Six human SDF-1 isoforms exist due to alternative splicing of CXCL12, the gene encoding SDF-1. Three isoforms are known for mouse and rat.
Alternate names: C-X-C motif chemokine 12, IRH, Intercrine reduced in hepatomas, PBSF, Pre-B cell growth- stimulating factor, SDF1A, SDF1B, Stromal cell-derived factor 1, hIRH

ID gène: 6387

NCBI Accession: NP_000600

UniProt: P48061

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling