RUNX3 anticorps

N° du produit ABIN498536

Détail du produit anti-RUNX3 anticorps

Antigène: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX3 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of RUNX3 protein. (region surrounding Arg182)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur RUNX3

Antigène: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Autre désignation: RUNX3 (RUNX3 Produits)

Synonymes: anticorps runxb, anticorps RUNX3, anticorps CBFA3, anticorps frrunx3, anticorps runx3, anticorps aml2, anticorps cbfa3, anticorps pebp2ac, anticorps AML2, anticorps Cbfa3, anticorps Pebp2a3, anticorps PEBP2aC, anticorps runt-related transcription factor 3, anticorps runt related transcription factor 3, anticorps runt related transcription factor 3 L homeolog, anticorps runx3, anticorps RUNX3, anticorps runx3.L, anticorps Runx3

Sujet: The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3), and belongs to the acute myeloid leukemia (AML) family. RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX3 is expressed in cells of hematopoietic origin, including myeloid and B-cell lines and spleen. By playing a role in controlling the growth and differentiation of gastric epithelial cells, RUNX3 is a strong candidate as a gastric cancer tumor suppressor. Specifically, hypermethylation inactivates the gene encoding RUNX3. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may aid in the diagnosis and risk assessment of gastric cancer.Synonyms: AML2, Acute myeloid leukemia 2 protein, CBF-alpha-3, CBFA3, Core-binding factor subunit alpha-3, Oncogene AML-2, PEA2-alpha C, PEBP2-alpha C, PEBP2A3, Polyomavirus enhancer-binding protein 2 alpha C subunit, Runt-related transcription factor 3, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit

Poids moléculaire: approx. 44 kDa

ID gène: 864

NCBI Accession: NP_001026850

UniProt: Q13761