EIF2S1 anticorps

N° du produit ABIN498644

Détail du produit anti-EIF2S1 anticorps

Antigène: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF2S1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of eIF2alpha protein. (region surrounding Ile45)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur EIF2S1

Antigène: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Autre désignation: EIF2A / EIF2S1 (EIF2S1 Produits)

Synonymes: anticorps EIF-2, anticorps EIF-2A, anticorps EIF-2alpha, anticorps EIF2, anticorps EIF2A, anticorps Eif2s1, anticorps eif2s1l, anticorps fb36a08, anticorps wu:fb36a08, anticorps zgc:56510, anticorps 0910001O23Rik, anticorps 2410026C18Rik, anticorps 35kDa, anticorps Eif2a, anticorps eIF2alpha, anticorps eif2a, anticorps CG9946, anticorps Dmel\\CG9946, anticorps Eif2alpha, anticorps IF2A_DROME, anticorps M(1)14C, anticorps M(1)19-153, anticorps M(1)8e3-10, anticorps deIF2alpha, anticorps eIF-2, anticorps eIF-2 a, anticorps eIF-2 alpha, anticorps eIF2 alpha, anticorps eIF2-alpha, anticorps eIF2a, anticorps eiF-2alpha, anticorps elF2alpha, anticorps l(1)14Cf, anticorps l(1)19-153, anticorps eukaryotic translation initiation factor 2 subunit alpha, anticorps eukaryotic translation initiation factor 2, subunit 1 alpha a, anticorps eukaryotic translation initiation factor 2, subunit 1 alpha, anticorps eukaryotic translation initiation factor 2 alpha subunit, anticorps Eukaryotic translation initiation factor 2 subunit 1, anticorps eukaryotic translation initiation factor 2 subunit alpha L homeolog, anticorps eukaryotic translation Initiation Factor 2alpha, anticorps EIF2S1, anticorps eif2s1a, anticorps Eif2s1, anticorps eif2s1, anticorps LOC693063, anticorps CNI00230, anticorps THAPSDRAFT_105, anticorps if2a, anticorps eif2s1.L, anticorps eIF-2alpha

Sujet: The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex is composed of three subunits, designated eIF2alpha, eIF2beta and eIF2gamma (eukaryotic translation initiation factor 2 alpha, beta and gamma, respectively), all of which work in concert to form a ternary complex with GTP and tRNA in the early stages of protein synthesis. eIF2alpha, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2alpha controls the rate of tRNA translation. When eIF2alpha is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2alpha is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.Synonyms: EIF2-A, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, eIF2 alpha

Poids moléculaire: approx. 38 kDa

ID gène: 1965

NCBI Accession: NP_004085

UniProt: P05198

Pathways: Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C