TRAF6 anticorps

N° du produit ABIN498675

Détail du produit anti-TRAF6 anticorps

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Mfn2 protein. (region surrounding His154)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TRAF6

Antigène: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Autre désignation: TRAF6 / RNF85 (TRAF6 Produits)

Synonymes: anticorps MGC:3310, anticorps RNF85, anticorps 2310003F17Rik, anticorps AI851288, anticorps C630032O20Rik, anticorps rnf85, anticorps traf6, anticorps xtraf6, anticorps CG10961, anticorps DTRAF2, anticorps Dmel\\CG10961, anticorps TRAF, anticorps TRAF2, anticorps TRAF6, anticorps Traf2, anticorps dTRAF2, anticorps dTRAF6, anticorps dTraf2, anticorps dtraf2, anticorps GB10539, anticorps fi15f02, anticorps wu:fi15f02, anticorps zgc:63704, anticorps TNF receptor associated factor 6, anticorps TNF receptor-associated factor 6, anticorps TNF receptor associated factor 6 L homeolog, anticorps TNF-receptor-associated factor 6, anticorps TNF receptor associated factor 6 S homeolog, anticorps TRAF6, anticorps Traf6, anticorps traf6.L, anticorps traf6, anticorps LOC551819, anticorps traf6.S

Sujet: Tumor necrosis factor receptor-associated factor 6 (TRAF6) regulates adaptive immunity, innate immunity and bone metabolism. TRAF6 is a ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IkappaB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys 63 of Ub. TRAF6 is essential for activating NFκB signaling pathway in response to interleukin-1 and Toll-like receptor ligands. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination and activating NFkappaB signaling pathway. TRAF6 interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways.Synonyms: Interleukin-1 signal transducer, RING finger protein 85, TNF receptor-associated factor 6

Poids moléculaire: approx. 58 kDa

ID gène: 7189

NCBI Accession: NP_004611

UniProt: Q9Y4K3

Pathways: Signalisation NF-kappaB, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway